Table II.
Participants' characteristics at enrollment
| Characteristic | Patients with PAD | Controls | P value |
|---|---|---|---|
| Participants enrolled | 44 | 42 | — |
| Age (y), median age (range) | 51.5 (21-78) | 51.5 (28-77) | .785 |
| Female patients, n (%) | 21 (47.7) | 25 (59.5) | .398 |
| Bronchiectasis present on CT, n (%) | 15 (34.1) | 1 (2.38) | .0002 |
| Smoking status | .872 | ||
| Current smoker | 3 | 2 | |
| Ex-smoker | 8 | 11 | |
| Never smoker | 33 | 29 | |
| Prophylactic antibiotic use, n (%) | 28 (63.6) | 0 (0.0) | <.0001 |
| Young child exposure >8 h/d | 11 (25.0) | 15 (35.7) | .280 |
| Immunoglobulin replacement therapy | 44 | 0 | <.0001 |
| IVIg | 20 | ||
| SCIg | 20 | ||
| fSCIg | 4 | ||
| IgG trough level∗ (g/L) (range) | 9.75 (6.18-15.3) | ||
| IgA (g/L) (range) | 0.06 (0.06-4.1) | ||
| IgM (g/L) (range) | 0.18 (0.05-5.1) | ||
| FEV1 (L), (Interquartile range)† | 2.60 (1.81-3.17) | 2.90 (2.34-3.43) | .07 |
| FEV1 predicted (%)‡ (Interquartile range)† | 87.0 (69.8-99.5) | 97.0 (88.5-108.5) | .0005 |
| Quality of life | |||
| 22-item Sino-Nasal Outcome Test§ (interquartile range) | 28 (16.0-43.0) | 8 (2.0-29.0) | .0003 |
| St George's Respiratory Questionnaires‖ (interquartile range) | 29.3 (15.6-49.6) | 7.89 (4.03-16.0) | <.0001 |
CT, Computed tomography; fSCIg, facilitated subcutaneous immunoglobulin; IVIg, intravenous immunoglobulin; SCIg, subcutaneous immunoglobulin.
Bold indicates statistical significance (P < .05).
Serum IgG level measured immediately before next IVIg infusion.
Unpaired t test.
Based on the European respiratory guidelines of 1993.
Sino-Nasal Outcome Test: a validated measure of burden of sinusitis, with 22 items scored between 0 and 5, with total score of 0 (best) and 110 (worst).
St George Respiratory Questionnaire: a validated measure of respiratory-related quality of life, scored between 0 (best) and 100 (worst). Median values are shown unless stated; P values were calculated using the Mann-Whitney test for continuous variables and Fisher exact test for categorical variables unless otherwise stated.