Table 1.
Epithelial populations in native human airways and lungs
| Region | Cell Type | Associated Markers for Cell Characterization | Cell Proportions in Native Lung |
|---|---|---|---|
| Proximal Airway | Ciliated Cell | FOXJ1, AcTUB | 48–70% [[122], [123]] |
| Goblet Cell | MUC5AC, MUC5B | 6–25% [[122], [124]] | |
| Club Cell | CCSP, SCGB1A1, SCGB3A2 | 7–11% [[122], [125]] | |
| Basal Cell | P63, KRT5, NGFR, ITGA6, ITGB4 | 12–30% [[122], [126]] | |
| Distal Lung | Alveolar epithelial cell type I (AEC I) | HOPX, PDPN, AQP5 | ~33% [127] |
| Alveolar epithelial cell type II (AEC II) | SPB, SPC, HT2-280 | ~66% [127] |