Table 1.
Experimental pKa shifts of benzimidazole and its derivatives upon complexation with CB7. pKa results were taken from ref.1
| Ligand | pKaFree | pKaComplex | ΔpKa |
|---|---|---|---|
| BZ | 5.5 | 9.0 | 3.5 |
| ABZ | 3.5 | 6.1 | 4.0 |
| CBZ | 4.5 | 7.0 | 3.8 |
| FBZ | 4.8 | 8.6 | 2.6 |
| TBZ | 4.6 | 8.6 | 2.5 |
Experimental pKa shifts of benzimidazole and its derivatives upon complexation with CB7. pKa results were taken from ref.1
| Ligand | pKaFree | pKaComplex | ΔpKa |
|---|---|---|---|
| BZ | 5.5 | 9.0 | 3.5 |
| ABZ | 3.5 | 6.1 | 4.0 |
| CBZ | 4.5 | 7.0 | 3.8 |
| FBZ | 4.8 | 8.6 | 2.6 |
| TBZ | 4.6 | 8.6 | 2.5 |