Table 2.

Characteristics of patients with biochemical POI and controls in the different studies

Studies	Number	Criteria of patient’s inclusion	Age
Butts et al. 2009 [38]	12 POF	FSH ≥ 11,4 IU/L and estradiol ≤293,6 pmol/L	30–37
	42 controls	Normal FSH, tubal factor or male infertility	23–37
Hanna et al. 2009 [39]	34 POF	Three-month amenorrhea, FSH > 40 IU/L before the age of 40	21–50
	108 controls	Overall population	17–55
Xu et al. 2017 [42]	120 POF	Regular cycles, FSH ≥ 10 UI/L, unilateral AFC < 5	≤ 40
	279 control (leukocytes) 90 controls (granulosa)	Lack of criteria
Miranda-Furtado et al. 2018 [40]	46 POF	Amenorrhea, FSH > 40 UI/L before the age of 40	18–41
	75 controls	Regular cycles, FSH < 10 UI/L
Sayban et al. 2018 [41]	40 POF	Six-month amenorrhea, FSH > 40 UI/L before the age of 40	<  40
	40 controls	Regular cycle, normal FSH