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. 2020 Aug 21;13:95. doi: 10.1186/s13048-020-00703-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The Effect of Metformin on Survival in Ovarian Cancer Patients. a Kaplan-Meier OS of ovarian cancer patients with (n = 32) or without (n = 705) metformin use. b The ovarian cancer-free incidence in female DM patients: metformin(+) (ever used)/insulin(+) (ever used) users (n = 24,033) and metformin(−) (never used)/insulin(−) (never used) users (n = 14,853) from the National Health Insurance Taiwanese Dataset. c Tumor proliferation (cell number, 2D-colony formation) and Western blot analyses of the indicated proteins in the AKT/mTOR pathway of mouse ovarian cancer cells treated with different concentrations of metformin. d Comparison of the mortality rates between groups with low and high protein expression by the half-division approach. Kaplan-Meier analysis assessed the correlations of the indicated proteins (AKT [total and pSer473], mTOR [total and pSer2448]) with the overall survival of patients; data from the cBioPortal TCGA database (TCGA Provisional, ovarian cancer genomics, n = 606). A log-rank p-value less than 0.05 indicated a significant difference in overall prognosis (*p < 0.05, **p < 0.01, ***p < 0.001)