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Metformin at a Clinically Relevant Dosage Inhibits Ovarian Cancer Growth through the AKT/mTOR Pathway. a-b Growth of mouse ovarian cancer cell line (MOSEC) in cells incubated for serial days with low-concentration metformin (0.5 mM). Met.: metformin. *: p < 0.05, by two-way ANOVA. c and d Cell viability and protein analyses of the AKT/mTOR pathway under treatment with metformin (0.5 mM) from day 2 to day 5 and when treatment was suspended from day 6 to day 8
