Table 2.

Metabolite information of each group after 28 days of treatment.

Id	TR (min)	Endogenous metabolites	Quantitatively results					HMDB
			MKR group	Model control group	Liu-Wei-Di-Huang group	Western medicine group	Normal control group
1	6.563	Oxalic acid	1.0081 ± 0.0647	1.1050 ± 0.0638	1.2981 ± 0.198	0.996 ± 0.126	1.2671 ± 0.0878	HMDB 00190
2	7.329	L-Lactic acid	0.1151 ± 0.0176	0.0670 ± 0.0423	0.1443 ± 0.065	0.0831 ± 0.0639	0.0708 ± 0.0105	HMDB 02329
3	8.244	Butyric acid	0.01684 ± 0.0013	0.01315 ± 0.0019	0.02088 ± 0.025	0.0136 ± 0.0057	0.023 ± 0.0043	HMDB 00357
4	9.466	3-Hydroxybutyric acid	0.0261 ± 0.0112	0.02191 ± 0.003	0.01906 ± 0.0122	0.01847 ± 0.0133	0.0135 ± 0.027	HMDB 00883
5	10.165	Urea	0.74953 ± 0.3128	0.69655 ± 0.1089	1.19208 ± 0.1639	0.84024 ± 0.2563	0.6210 ± 0.0228	HMDB 00294
6	10.756	Phosphoric acid	0.2025 ± 0.0374	0.25623 ± 0.0383	0.30031 ± 0.0406	0.23334 ± 0.0377	0.2436 ± 0.096	HMDB 02142
7	11.283	L-Proline	0.01115 ± 0.0125	0.00575 ± 0.0092	0.01983 ± 0.0202	0.0093 ± 0.0004	0.0083 ± 0.0024	HMDB 00162
8	11.469	Glycine	0.02126 ± 0.0054	0.01324 ± 0.0074	0.01126 ± 0.0134	0.00862 ± 0.0075	0.0724 ± 0.0012	HMDB 00123
9	10.397	Serine	0.00258 ± 0.0023	0.00646 ± 0.0069	0.00137 ± 0.0017	0.00148 ± 0.0019	0.00132 ± 0.0009	HMDB 00187
10	11.185	L-Threonine	0.02325 ± 0.0226	0.02313 ± 0.0046	0.03143 ± 0.0357	0.02225 ± 0.0106	0.0235 ± 0.0109	HMDB 00167
11	14.985	L-Aspartic acid	0.00942 ± 0.002	0.0082 ± 0.0056	0.00485 ± 0.0042	0.00481 ± 0.0068	0.00422 ± 0.0058	HMDB 00191
12	16.033	Erythronic acid	0.1006 ± 0.0172	0.06606 ± 0.0155	0.10925 ± 0.0136	0.05299 ± 0.001	0.06129 ± 0.0034	HMDB 00182
13	18.024	L-Glutamine	0.00405 ± 0.0036	0.0082 ± 0.0078	0.00763 ± 0.0062	0.0088 ± 0.012	0.0062 ± 0.0013	HMDB 00641
14	19.076	Citric acid	0.05004 ± 0.0105	0.02826 ± 0.004	0.02627 ± 0.0077	0.02318 ± 0.0053	0.0136 ± 0.0015	HMDB 00094
15	19.556	N-Acetyl-D-glucosamine	0.01069 ± 0.0094	0.00412 ± 0.0038	0.00769 ± 0.0025	0.00142 ± 0.002	0.0011 ± 0.0001	HMDB 00660
16	20.427	D-Galactose	0.0155 ± 0.0027	0.01657 ± 0.0017	0.01977 ± 0.0087	0.02058 ± 0.0041	0.00188 ± 0.0041	HMDB 00143
17	22.175	D-Mannose	0.01267 ± 0.012	0.01474 ± 0.0128	0.02510 ± 0.0041	0.01819 ± 0.0013	0.0186 ± 0.017	HMDB 00169
18	22.667	Mannitol	0.44126 ± 0.0853	0.43875 ± 0.0532	0.60073 ± 0.1016	0.46482 ± 0.0544	0.5924 ± 0.0454	HMDB 00143
19	22.386	D-Glucose	1.58832 ± 0.1782	1.67471 ± 0.0979	1.27004 ± 0.1011	1.39533 ± 0.208	1.3509 ± 0.1477	HMDB 00122
20	22.803	L-Lysine	0.01849 ± 0.018	0.00986 ± 0.0104	0.0481 ± 0.018	0.01357 ± 0.0078	0.0126 ± 0.0010	HMDB 00182
21	23.076	L-Tyrosine	0.00374 ± 0.0065	0.00357 ± 0.0037	0.02989 ± 0.0305	0.00216 ± 0.0024	0.0219 ± 0.0032	HMDB 00158
22	22.982	D-Turanose	0.00102 ± 0.0018	0.0136 ± 0.0062	0.01904 ± 0.0079	0.0268 ± 0.0038	0.0211 ± 0.0016	HMDB 11740
23	23.734	D-Arabinose	0.02608 ± 0.0115	0.1043 ± 0.0943	0.05253 ± 0.0453	0.09482 ± 0.0859	0.0743 ± 0.0161	HMDB 29942
24	24.877	Hexadecanoic acid	0.3109 ± 0.0146	0.27448 ± 0.0968	0.22018 ± 0.0698	0.2133 ± 0.0317	0.15475 ± 0.0359	HMDB 00220
25	25.411	Myo-inositol	0.02709 ± 0.0011	0.04054 ± 0.0043	0.05513 ± 0.0209	0.03449 ± 0.0027	0.00611 ± 0.0018	HMDB 00211
26	27.025	Linoleic acid	0.09659 ± 0.0158	0.14966 ± 0.0097	0.13681 ± 0.0508	0.10969 ± 0.035	0.1248 ± 0.0049	HMDB 00673
27	27.1	Elaidic acid	0.07306 ± 0.0179	0.10672 ± 0.0386	0.1192 ± 0.0312	0.10621 ± 0.0527	0.1804 ± 0.0036	HMDB 00573
28	27.404	Octadecanoic acid	0.1304 ± 0.0040	0.1216 ± 0.0178	0.10271 ± 0.034	0.10193 ± 0.0115	0.09816 ± 0.018	HMDB 00827
29	28.714	Arachidonic acid	0.0223 ± 0.0016	0.0252 ± 0.0025	0.02653 ± 0.0102	0.0192 ± 0.009	0.0141 ± 0.0018	HMDB 01043
30	32.967	Cholesterol	0.1060 ± 0.0898	0.07909 ± 0.0757	0.0413 ± 0.0837	0.0323 ± 0.0075	0.0451 ± 0.0209	HMDB 00067