Figure 6.

MicroRNA-mRNA networks in the atherosclerosis signaling pathway after TCDD and Aroclor1254 coexposure in ApoE^−/− mice. The atherosclerosis signaling pathway was significantly altered after treatment with TCDD and Aroclor1254. The mRNAs with red meant altered genes after treatment. The solid arrow between miRNA and mRNAs denoted the interaction between miRNAs and mRNAs. Significantly upregulated or downregulated mRNAs: fold change > 2 (p value < 0.05) or fold change < 2 (p value < 0.05). Significantly upregulated genes or downregulated miRNAs: fold change > 1.5 (p value < 0.05) or fold change < 1.5 (p value < 0.05), respectively.