Table 3.

Behavior After Intravenous Injection of CT-928

Dose (mg/kg)	Vocalization 0–20 min	Activity During 0–20 min	Activity During 20–40 min	Activity During 40–120 min
0.6	1/8	normal 8/8	slightly hyperactive 4/8 hypoactive 4/8	normal 8/8
1.2	2/8	hyperactive 6/8 hypoactive 2/8	hyperactive 6/8 hypoactive 2/8	hypoactive 7/8 normal 1/8
2.3	3/8	hyperactive 8/8	hyperactive 8/8	hypoactive 8/8
6.9	3/8	hyperactive 8/8	hyperactive 8/8	hypoactive 8/8
20.7	6/8 †	hypoactivity with agitated episodes 6/6	‡	‡

Notes: ^†Two mice died of rapid onset respiratory depression before they could be euthanized: ^‡Six mice suffered respiratory distress and were euthanized as per Animal Care Guidelines.