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. 2020 Aug 17;12:7305–7317. doi: 10.2147/CMAR.S259677

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© 2020 Yang et al.

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IE2 promotes U87MG cell proliferation and expression of inflammatory cytokines. (A) Representative images of human glioma tissues showing the pattern of IE2 expression. Peritumoral tissues do not show IE2 expression. The immunohistochemical staining for IE is marked by arrows. Scar bar=400um. (B) Protein expression level of p53 after transfection of IE2. (C) MTT assay shows the proliferation of U87MG cells after transfection of IE2, *P<0.05 vs pcDNA3.1. (D and E) After transfection of IE2 for 48h, the expression of IL-6 and IFN-β mRNA in U87MG cells, **P<0.01 vs pcDNA3.1. n=3.

Abbreviations: IE2, intermediate-early gene 2; IL-6, interleukin-6; IFN-β, interferon-β.