Table 4.
Multivariate logistic regression analysis between other factors on impaired GFR among patients with T2DM.
| Factors | Crude OR (95% CI) | P value | Adjusted OR (95% CI) | P value |
|---|---|---|---|---|
| Female | 1.15 (1.09, 1.2) | <0.001 | 1.01 (0.54, 1.91) | 0.964 |
| Age (years) | ||||
| <50 | Reference | 1 | Reference | 1 |
| 50-59 | 2.2 (2.00, 2.43) | <0.001 | 2.97 (0.77, 11.52) | 0.114 |
| 60-69 | 5.39 (4.90, 5.93) | <0.001 | 11.68 (3.13, 43.61) | <0.001 |
| >70 | 12.55 (11.36, 13.87) | <0.001 | 21.85 (5.64, 84.69) | <0.001 |
| BMI (kg/m2) | ||||
| BMI ≤22.9 | Reference | 1 | Reference | 1 |
| BMI 23-24.9 | 0.75 (0.70, 0.80) | <0.001 | 0.98 (0.46, 2.09) | 0.950 |
| Obese I, BMI 25-29.9 | 0.66 (0.63, 0.70) | <0.001 | 0.71 (0.33, 1.52) | 0.375 |
| Obese II, BMI ≥30 | 0.52 (0.48, 0.56) | <0.001 | 0.86 (0.29, 2.57) | 0.780 |
| Waist circumference (cm) | 0.99 (0.99, 0.99) | <0.001 | 0.99 (0.95, 1.02) | 0.423 |
| Smoking | 0.90 (0.84, 0.96) | 0.002 | 1.35 (0.60, 3.01) | 0.464 |
| Systolic BP (mmHg) | ||||
| <120 | Reference | 1 | Reference | 1 |
| 120-129 | 1.15 (1.07, 1.24) | <0.001 | 2.72 (1.05, 7.00) | 0.038 |
| 130-139 | 1.32 (1.23, 1.42) | <0.001 | 3.21 (1.30, 7.96) | 0.012 |
| >140 | 1.81 (1.68, 1.95) | <0.001 | 2.34 (0.92, 5.98) | 0.075 |
| Diastolic BP (mmHg) | ||||
| <80 | Reference | 1 | Reference | 1 |
| 80-89 | 0.64 (0.61, 0.68) | <0.001 | 0.52 (0.28, 1.03) | 0.052 |
| 90-99 | 0.54 (0.47, 0.61) | <0.001 | 0.66 (0.15, 2.93) | 0.581 |
| ≥100 | 0.94 (0.62, 1.45) | 0.792 | 1.00 (0.00, 1.00) | 0.999 |
| HemoglobinA1C (%) | ||||
| <6 | 1.14 (1.05, 1.24) | 0.002 | 3.71 (1.65, 8.32) | 0.001 |
| 6-7 | Reference | 1 | Reference | 1 |
| >7 | 0.87 (0.81, 0.92) | <0.001 | 2.53 (1.38, 4.63) | 0.003 |
| Hemoglobin (g/dL) | 0.69 (0.68, 0.71) | <0.001 | 0.86 (0.73, 1.01) | 0.071 |
| Serum uric acid (mg/dL) | 1.42 (1.38, 1.46) | <0.001 | 2.06 (1.73, 2.46) | <0.001 |
| HDL-cholesterol (mg/dL) | 0.99 (0.99, 0.99) | <0.001 | 1.00 (0.99, 1.02) | 0.864 |
| UACR (mg/gCr) | ||||
| <30 | Reference | 1 | Reference | 1 |
| 30-300 | 2.10 (1.77, 2.50) | <0.001 | 2.47 (1.39, 4.40) | 0.002 |
| >300 | 5.15 (3.77, 7.03) | <0.001 | 3.54 (1.50, 8.40) | 0.004 |
All associations significant at P<0.05.
Abbreviation: BP: blood pressure; BMI: body mass index; UACR: urine albumin creatinine ratio.
aAdjusted by age, sex, BMI, waist circumference, smoking, systolic BP, diastolic BP, HA1C, hemoglobin, serum uric acid, triglycerides, HDL-cholesterol, and albuminuria.