Table 2.
Effect of Genistein on the Levels of Plasma Cytokines of ob/ob Mice
| Cytokine (pg/mL) | Lean SD | ob/ob SD | ob/ob G |
|---|---|---|---|
| LIX | 3176±1265 (6) | 8344±1209 (7)* | 3721±974 (8)# |
| IL-1a | 91.7±30.1 (6) | 273.5±72.3 (6)* | 92.8±14.7 (7) # |
| KC (CXCL1) | 36.7±8.1 (6) | 83.8±11.5 (7)* | 71.5±7.6 (8) |
| MCP-1 | 23.1±4.9 (6) | 46.4±7.7 (7)* | 36.8±5.9 (8) |
| IL-2 | 2.9±0.3 (6) | 2.8±0.5 (7) | 3.2±0.4 (8) |
| IL-4 | 0.1±0.01 (6) | 0.2± 0.1(5) | 0.1± 0.01 (6) |
| IL-5 | 6.7±0.9 (6) | 2.8±0.4 (6)* | 2.9±0.4 (8) |
| IL-6 | 0.8±0.2 (4) | 2.5±0.6 (5)* | 4.7±2.7 (3) |
| IL-7 | 6.2±2.7 (6) | 29.9±20.2 (7) | 3.9±1.8 (5) |
| IL-10 | 2.9±0.3 (6) | 2.7±0.8 (6) | 1.7±0.2 (7) |
| IL-12 (p70) | 2.6±0.2 (5) | 14.9±6.8 (6) | 1.5±0.2 (6) |
| IL-13 | 50.3±4.7 (6) | 36.8±2.7 (7)* | 26.6±3.3 (8) # |
| IL-17 | 11.7±1.0 (6) | 8.8±1.2 (7) | 10.3±2.1 (8) |
| IL-1B | 3.3±0.6 (6) | 2.4±0.2 (3) | 3.8±1.8 (3) |
| GM-CSF | 7.9±0.9 (6) | 8.4±1.4 (6) | 7.3±0.6 (6) |
| MIP-2 | 39.0±2.9 (6) | 39.9±1.8 (7) | 36.7±2.1 (8) |
| TNFα | 3.5±0.3 (6) | 3.2±0.5 (6) | 2.7±0.5 (8) |
Notes: Values are expressed as mean ± SEM for 3–8 mice per group. Numbers in parentheses indicate the sample size for each cytokine assayed per group. *p < 0.05 compared to lean mice fed the SD. #p < 0.05 compared to ob/ob mice fed the SD.
Abbreviations: SD, standard diet; G, genistein; LIX, lipopolysaccharide-induced; CXC, chemokine; IL, interleukin; KC CXCL1, C-X-C motif chemokine-1; MCP, monocyte chemoattractant protein; GM-CSF, granulocyte-macrophage colony-stimulating factor; MIP, macrophage inflammatory protein; TNFα, tumor necrosis factor alpha.