Table 2.

KEGG signaling pathways and their association with angiogenesis and wound healing.

KEGG signaling pathway	Role in angiogenesis/wound healing	References	log10 (p value)
Adherens junction	Wound closure	Fenteany et al., 2000 [47]	5.10E − 07
HIPPO	Organ regeneration	Juan & Hong, 2016 [48]; Lee et al., 2014 [49]; Zhao et al., 2011 [51]; Wang et al., 2017 [50]	3.73E − 06
p53	Promotes VEGF expression and angiogenesis	Farhang Ghahremani et al., 2013 [52]	9.63E − 06
TGF-beta	Skin wound healing	Finnson et al., 2013 [53]; Ramirez et al., 2014 [54]	2.39E − 05
ECM-receptor interaction	Wound repair	Olczyk et al., 2014 [55]	4.53E − 05
Focal adhesion	Cell migration; angiogenesis	Zhao & Guan, 2011 [56]	0.000175201
mTOR	Interconnected to PI3K-Akt pathway to accelerate epithelial wound healing; angiogenesis	Castilho et al., 2013 [56]; Karar & Maity, 2011 [59]	0.000176029
HIF-1	Accelerating wound healing by enhancing angiogenesis	Hong et al., 2014 [60]	0.000538735
ErbB	Mediates proliferation and migration of keratinocytes in wound healing (ErbB1)	Pastore et al., 2008 [61]	0.001490837
FoxO	Upstream in the activation of both TGF-beta and PI3K-Akt signaling pathways		0.002880647
Wnt	Participates to each stage of the healing process	Whyte et al., 2012 [62]	0.00326995
Notch	Angiogenesis and endothelial cell formation; essential in organ regeneration; vasculature repair after brain trauma and wound healing	Carlson et al., 2007 [63]; Raya et al., 2003 [66]; Ran et al., 2015 [65]; Chigurupati et al., 2007 [64]	0.004876559
Neurotrophin	Novel regulator of angiogenesis	Kraemer & Hempstead, 2003 [67]	0.009582793
MAPK	Skin reepithelialization	Deng et al., 2006 [68]	0.008652606
Insulin	Upstream to PI3k/Akt and mTOR	Karar & Maity, 2011 [59]	0.014139516

DIANA tool analysis of the 87 miRNAs considered significantly upregulated in fetal vs. adult dermal cell-derived EVs.