Figure 1. Mutation density has a strong correlation with time in isolates carrying both 14408 C >T and 23403 A >G mutations.

(A-B) Distribution of average synonymous mutations per day in (A) isolates carrying the reference nucleotide for both 14408 and 23403 (WT), and (B) isolates carrying the mutations of interest at both sites (MT). (C-D) Distribution of non-synonymous mutations in (C) WT isolates, and (D) MT isolates. Red dots indicate average density of samples from the UK, blue dots indicate the average density of US samples. The correlation coefficients are calculated using Spearman correlation using the combined sets of both countries.