Table 2B.

DAPHNE's Performance on External Validations: Sensitivity, Specificity and Corresponding 95% CIs for Referral Level Output to Detect Referral, PDR and DME, and PDR Level Output to Detect PDR on the Saudi Arabian Dataset

Disease Level	Daphne Predicted Results	Sensitivity	Specificity
Referral vs. Non- Referral	Referral	97.1% (95.1%–97.25%)	90.33% (85.71%–92.17%)
	PDR	100% (94.5%–100%)	—
	DME	100% (94.5%–100%)	—
PDR vs. Non-PDR	PDR	98.23% (93.3%–99.6%)	83.78% (82.12%–88.87%)

The ground truth of DME was obtained from eye clinic, to assess the detection of DME markers by the DAPHNE detector.