. 2020 Aug 22;10(4):e158. doi: 10.1002/ctm2.158

TABLE 2.

Advantages and disadvantages of the different technologies used to detect COVID‐19 antibodies

Technology	ELISA	CLIA	LFIA
Detection time	1.5‐2.5 h ¹²³	0.5 h ⁵⁰	10‐15 min ⁵⁷ , ¹²⁴
Sensitivity	65‐98% ¹²³ , ¹²⁵ , ¹²⁶ , ¹²⁷ , ¹²⁸	77‐100% ¹¹⁴ , ¹²⁵ , ¹²⁷ , ¹²⁹	69‐93% ¹²³ , ¹²⁴ , ¹²⁵ , ¹²⁷ , ¹³⁰
Specificity	71‐100% ¹²³ , ¹²⁵ , ¹²⁶ , ¹²⁷ , ¹²⁸	90‐100% ¹¹⁴ , ¹²⁵ , ¹²⁷ , ¹²⁹	80‐100% ¹²³ , ¹²⁴ , ¹²⁵ , ¹²⁷ , ¹³⁰
Advantages	Simple operation, low cost, high‐throughput	Higher sensitivity and specificity, broad linearity, automated	Simple operation, low cost, rapid
Disadvantage	Time‐consuming, Vulnerable to contamination	Need Supporting chemiluminescence instruments	Low sensitivity during early SARS‐COV‐2 infection
Application	Diagnostics, ¹³¹ epidemiological surveillance, ¹³² discharge from hospital ¹³³	Diagnostics ⁴⁹ , epidemiological surveillance ⁵⁰ , discharge from hospital	Diagnostics, ¹²⁴ Epidemiological surveillance ¹³⁴