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. 2020 Aug 12;11(8):682. doi: 10.1038/s41419-020-02851-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Expression profile of circRNAs in three paired OSCC and matched OSF tissues as well as in three NBM tissues. b, c Six consistently deregulated circRNAs in tissue samples (b) and OSCC cell lines (c). d RNase R exonuclease and actinomycin D assays confirmed the circular structure of circEPSTI1. e The subcellular distribution of circEPSTI1 was cytoplasmic, as shown by FISH (scale bar 10 μm). f The expression level of circEPSTI1 in 154 OSCC and matched OSF tissues was analyzed by RT-qPCR. g ROC curve analysis revealed that circEPSTI1 could sensitively discriminate OSCC from OSF and OSF from NBM. h Kaplan–Meier analysis of the correlation between circEPSTI1 expression and OS as well as PFS. ***P < 0.001; **P < 0.01; *P < 0.05.