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. 2020 Aug 12;11(8):682. doi: 10.1038/s41419-020-02851-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The protein levels of LTBP2 were accordingly altered by treatment with circEPSTI1 or miR-942-5p. b, c Knockdown or overexpression of circEPSTI1 markedly decreased or increased the expression of LTBP2 at both the protein (b) and mRNA (c) levels, which can be reversed by miR-942-5p mimics or inhibitors. d The increase or decrease in the expression level of LTBP2 induced by circEPSTI1 overexpression or knockdown was reversed by miR-942-5p mimics or inhibitors as demonstrated by IF staining (scale bar 100 μm). e The expression level of LTBP2 in 154 OSCC and matched OSF tissues was analyzed by real-time PCR. f Kaplan–Meier analysis of the correlation between the expression levels of LTBP2, circEPSTI1/LTBP2, miR-942-5p/LTBP2, or circEPSTI1/miR-942-5p/LTBP2 and OS as well as PFS. ***P < 0.001; **P < 0.01; *P < 0.05.