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. 2020 Aug 12;11(8):682. doi: 10.1038/s41419-020-02851-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a The increases in the protein levels of p-PI3K, p-Akt, and p-mTOR after circEPSTI1 overexpression were significantly attenuated by BEZ235 treatment. b–f BEZ235 attenuated the circEPSTI1 overexpression-induced proliferation and invasion of OSCC cells, as evidenced by the growth curve assays (b), EdU assays (c, scale bar 100 μm), wound healing assays (d scale bar 500 μm), and transwell assays (e scale bar 100 μm) and nude mouse xenograft assays in vivo (f). ***P < 0.001; **P < 0.01; *P < 0.05.