Appendix Table B.4:

Sensitivity Analyses of Central Obesity Mortality Risk, 1988–2015 NHANES-LMF (Ages 30–74)

	High Waist-to-Height Ratio Cutoff at 0.6
	All-Cause				Underlying Hyp./Diab.				CVD				Cardiometabolic
	HR		95% CI		HR		95% CI		HR		95% CI		HR		95% CI
High Waist-to-Height Ratio	1.81	**	1.45	2.25	5.42	***	2.95	9.94	3.04	***	1.90	4.86	2.37	***	1.63	3.45
High WtHR X Education (ref. BA+)
Less than HS	0.75	*	0.59	0.96	0.46	*	0.25	0.84	0.50	**	0.30	0.83	0.69		0.46	1.02
HS or Some College	0.83		0.65	1.06	0.45	*	0.24	0.85	0.51	*	0.29	0.90	0.70		0.45	1.10
	Controlling for Previous Weight Status (Based on Maximum BMI and Current BMI)
	All-Cause				Underlying Hyp./Diab.				CVD				Cardiometabolic
	HR		95% CI		HR		95% CI		HR		95% CI		HR		95% CI
High Waist-to-Height Ratio	1.66	***	1.26	2.17	1.70		0.63	4.56	4.06	***	1.89	8.73	2.77	***	1.66	4.63
High WtHR X Education (ref. BA+)
Less than HS	0.67	*	0.48	0.95	0.92		0.31	2.78	0.31	*	0.12	0.78	0.47	*	0.26	0.86
HS or Some College	0.68	*	0.50	0.95	0.60		0.20	1.79	0.25	**	0.11	0.58	0.40	**	0.22	0.71
	Controlling for Income-to-Needs Ratio
	All-Cause				Underlying Hyp./Diab.				CVD				Cardiometabolic
	HR		95% CI		HR		95% CI		HR		95% CI		HR		95% CI
High Waist-to-Height Ratio	1.61	**	1.22	2.13	2.45		0.89	6.76	4.36	***	1.99	9.59	2.98	***	1.78	5.00
High WtHR X Education (ref. BA+)
Less than HS	0.64	*	0.45	0.91	0.95		0.32	2.87	0.30	*	0.12	0.77	0.48	*	0.26	0.88
HS or Some College	0.69	*	0.50	0.95	0.63		0.21	1.88	0.26	**	0.11	0.60	0.41	**	0.23	0.74
	Central Obesity Defined by Maximum BMI
	All-Cause				Underlying Hyp./Diab.				CVD				Cardiometabolic
	HR		95% CI		HR		95% CI		HR		95% CI		HR		95% CI
Maximum BMI Group (ref. Normal [18.5–24.9])
Underweight (<18.5)	-		-	-	-		-	-	-		-	-	-		-	-
Overweight (25.0–29.9)	0.72		0.50	1.04	1.58		0.56	4.46	0.66		0.33	1.32	0.61		0.30	1.22
Obese, Class I (30.0–34.9)	1.10		0.72	1.70	3.72	*	1.25	11.11	2.25	*	1.08	4.71	1.48		0.79	2.78
Obese, Class II/III (35.0+)	1.63	*	1.06	2.49	7.30	***	2.50	21.36	3.07	**	1.64	5.73	2.06	*	1.14	3.72
Max. BMI (ref. Normal) X Education (ref. BA+)
Less than HS X Underweight	-		-	-	-		-	-	-		-	-	-		-	-
Less than HS X Overweight	1.08		0.72	1.61	0.72		0.25	2.09	1.28		0.57	2.84	1.53		0.67	3.50
Less than HS X Obese, Class I	0.80		0.51	1.27	0.48		0.15	1.52	0.43		0.18	1.01	0.74		0.37	1.50
Less than HS X Obese, Class II/III	0.75		0.48	1.18	0.41		0.13	1.31	0.48	*	0.24	0.96	0.86		0.46	1.61
HS or SC X Underweight	-		-	-	-		-	-	-		-	-	-		-	-
HS or SC X Overweight	1.36		0.91	2.03	0.49		0.15	1.67	1.52		0.68	3.38	1.62		0.74	3.57
HS or SC X Obese, Class I	1.00		0.64	1.57	0.38		0.12	1.20	0.59		0.25	1.36	0.88		0.44	1.78
HS or SC X Obese, Class II/III	1.10		0.71	1.73	0.44		0.14	1.32	0.72		0.31	1.70	1.15		0.55	2.40

Notes:

N=40,058.

Age at death restricted to 85.

All models control for age, cohort, gender, race/ethnicity, nativity, region, and smoking status.

Significance based on two-tailed t-test, indicated as:

^*p<0.05;

^**p<0.01;

^***p<0.001.