Table 3.

Target Statistics (Median (Interquartile Range)) for Modeled, Sampled Networks^a Under Scenarios 3 and 4 As Compared With an Empirical Network of Extensively Drug-Resistant Tuberculosis Cases, KwaZulu-Natal, South Africa, 2011–2014

	Degree and Percentile of Degree Distribution
Type of Sampling and Mean Degree	10th Percentile c	25th Percentile	Median	75th Percentile	Maximum	P Value b
Target statistics for empirical network
5-SNP threshold	0	0	1	7	62
3-SNP threshold	0	0	0	1	22
Cases sampled preferentially by smear status (scenario 3)d
50/50 smear−/+ (empirical network: 30/70 smear−/+)
2	0 (0–0)	0 (0–0)	0 (0–0)	1 (1–1)	4 (4–5)	0 (0–0)
5	0 (0–0)	0 (0–0)	0 (0–0)	1 (1–2)	7 (7–8)	0 (0–0)
10	0 (0–0)	0 (0–0)	1 (1–1)	3 (3–3)	11 (10–12)	0 (0–0)
20	0 (0–0)	1 (1–1)	3 (2–3)	6 (6–6)	18 (17–19)	0 (0–0)
70/30 smear−/+ (empirical network: 30/70 smear−/+)
2	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–1)	4 (4–5)	0 (0–0)
5	0 (0–0)	0 (0–0)	0 (0–0)	1 (1–1)	7 (6–7)	0 (0–0)
10	0 (0–0)	0 (0–0)	1 (1–1)	2 (2–3)	11 (10–12)	0 (0–0)
20	0 (0–0)	0 (0–1)	2 (2–2)	5 (5–5)	19 (18–21)	0 (0–0)
Unmeasured factor (scenario 4) (40×, P = 0.10)
2	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	7 (6–8)	0 (0–0)
5	0 (0–0)	0 (0–0)	0 (0–0)	1 (1–1)	14 (12–15)	0 (0–0)
8	0 (0–0)	0 (0–0)	0 (0–0)	1 (1–1)	30 (28–32)	0 (0–0)
10	0 (0–0)	0 (0–0)	0 (0–0)	1 (1–1)	36 (34–38)	0 (0–0)
20	0 (0–0)	0 (0–0)	0 (0–0)	2 (2–3)	62 (60–63)	0 (0–0.002)

Abbreviations: SNP, single nucleotide polymorphism; TB, tuberculosis; TRAX Study, Transmission Study of XDR TB; XDR, extensively drug-resistant.

^a 1,000 networks were simulated from each model; each modeled network was sampled once.

^b P values from a Kolmogorov-Smirnov test with a 2-sided alternative hypothesis, calculated using 1,000 bootstrap samples. P values shown as 0 were less than 2.2e-16.

^c Median of the 10th percentile of the degree distribution from 1,000 modeled, sampled networks.

^d Smear distribution among TRAX cases (in empirical network): 32% smear-negative, 68% smear-positive.