Table 5.

Toxicity of herba patriniae.

Extract	Dosage	Subject	Adverse reaction	Reference
PS, root, methanol extract	–	mice	increased the serum aminotransferase and caused histopathological changes	Wang (2009)
PS	200 mg/kg	patient	polyuria	Wang (2009)
PS	200 mg/kg	mice	polyuria	Wang (2009)
PS, ethanol extract	30 g crude drug/kg	mice	mild diarrhea and mild respiratory depression	Wang and Sun (1997)
PS, rhizome and root, 60% ethanol extract	2-4 tablets (1 g crude drug/tablet), 2–3 times daily, for 10 days	patient	dryness in the mouth and stomach discomfort	Wang et al. (1983)
PS, root, ethanol extract	5–10 mL (1 g crude drug/mL), 2–3 times daily, for 10–14 days	patient	temporary stomach discomfort or blushing in the face	Luo et al. (1986)
PS, root, 60% ethanol extract	2-4 tablets (1 g crude drug/tablet), 2–3 times daily, for 10–14 days	patient	dryness in the mouth and stomach discomfort	Luo et al. (1986)
PS, root, volatile oil extract	20 mg/capsule, 1–2 capsules daily, for 10–14 days	patient	Nauseous or sleepy the next day	Luo et al. (1986)

Patrinia scabiosafolia Fisch. (PS).