Table 7.

The main pharmacokinetic parameters of the components after oral administration of Shenyanyihao oral solution in rats (n = 6, mean ± SD).

Parameters	Stachydrine	Danshensu	Chlorogenic acid	Protocatechuic acid	Plantamajoside	Aesculetin	Isoquercitrin	Ferulic acid	Baicalin	Baicalein
t 1/2 (h)	9.09 ± 0.51	3.91 ± 2.34	16.72 ± 3.32	11.35 ± 2.23	12.33 ± 3.92	14.43 ± 4.17	26.39 ± 3.89	11.84 ± 4.98	5.01 ± 0.52	11.72 ± 4.78
T max  (h)	3.20 ± 1.10	0.47 ± 0.08	1.30 ± 0.57	0.50 ± 0.00	1.40 ± 0.22	1.00 ± 0.00	0.50 ± 0.00	0.17 ± 0.00	2.80 ± 1.10	3.60 ± 0.89
C max (ng/ml)	2673.0 ± 163.0	181.79 ± 59.58	3.53 ± 0.52	26.19 ± 11.64	1.31 ± 0.23	1.65 ± 0.15	1.65 ± 0.23	70.24 ± 19.09	2983.4 ± 1344.3	14.25 ± 2.59
AUC0‐t (ng/ml∗h)	39256.8 ± 4031.7	556.04 ± 165.66	17.05 ± 2.86	41.96 ± 11.42	3.99 ± 0.44	8.23 ± 1.70	4.75 ± 0.68	76.39 ± 21.43	26525.1 ± 15523.7	106.77 ± 46.19
AUC0‐∞ (ng/ml∗h)	40196.0 ± 4088.2	569.72 ± 165.31	21.95 ± 3.34	45.80 ± 12.60	5.01 ± 0.71	11.64 ± 2.41	8.98 ± 1.33	95.70 ± 25.36	26566.8 ± 15520.4	128.95 ± 53.59
AUMC0‐∞ (ng/ml∗h2)	515393.7 ± 55002.7	2049.56 ± 1061.35	338.84 ± 99.46	307.02 ± 152.54	66.31 ± 28.63	223.19 ± 97.81	304.35 ± 69.29	1254.35 ± 628.41	229094.2 ± 146621.6	2190.95 ± 1741.10
MRT0‐∞ (h)	12.82 ± 0.25	3.56 ± 1.71	15.42 ± 3.31	6.60 ± 2.26	12.76 ± 4.47	18.80 ± 5.01	33.67 ± 3.63	12.50 ± 4.16	8.71 ± 2.00	15.16 ± 5.91
V d (l/kg)	0.76 ± 0.11	13.67 ± 8.51	1001.03 ± 202.53	24.09 ± 4.86	79.97 ± 18.00	7.31 ± 2.02	127.91 ± 13.82	18.01 ± 5.2	12.89 ± 8.01	131.54 ± 23.79
CL (l/kg/h)	0.06 ± 0.01	2.47 ± 0.86	41.83 ± 6.79	1.52 ± 0.47	4.68 ± 0.77	0.36 ± 0.07	3.40 ± 0.50	1.13 ± 0.39	1.71 ± 0.90	8.72 ± 3.03