Table 1.
The univariate and multinomial logistic regression analysis between high and low levels groups of biomarkers.
| Totle patients | Univariate | P | Multivariate | P | ||||
|---|---|---|---|---|---|---|---|---|
| Male | Cut-point | AUC | OR (95% CI) | OR (95% CI) | ||||
| NEU | 1474 | 867 | 4.82 | 0.5396 | 1.866 (1.378,2.528) | <0.0001 | 1.593 (1.163,2.181) | 0.0037 |
| WBC | 1474 | 867 | 7.57 | 0.5129 | 1.574 (1.139,2.175) | 0.0060 | 1.371 (0.982,1.915) | 0.0640 |
| LYM | 1474 | 867 | 1.38 | 0.6174 | 0.437 (0.330,0.579) | <0.0001 | 0.444 (0.332,0.592) | <0.0001 |
| CEA | 1474 | 867 | 4.84 | 0.6004 | 1.923 (1.454,2.544) | <0.0001 | 1.778 (1.336,2.366) | <0.0001 |
| CA19-9 | 1474 | 867 | 29.9 | 0.5475 | 2.077 (1.530,2.819) | <0.0001 | 1.975 (1.442,2.704) | <0.0001 |
| CA125 | 1474 | 867 | 19.5 | 0.7005 | 5.466 (4.075,7.331) | <0.0001 | 5.148 (3.781,7.009) | <0.0001 |
| ALB | 1474 | 867 | 40.8 | 0.6573 | 0.340 (0.249,0.464) | <0.0001 | 0.392 (0.285,0.539) | <0.0001 |
| ALP | 1474 | 867 | 63 | 0.5419 | 0.671 (0.497,0.904) | 0.0088 | 0.619 (0.455,0.842) | 0.0023 |
| GGT | 1474 | 867 | 67 | 0.5037 | 1.830 (1.080,3.101) | 0.0247 | 1.712 (0.995,2.944) | 0.0520 |
| Tp | 1474 | 867 | 62.8 | 0.6403 | 0.402 (0.303,0.532) | <0.0001 | 0.448 (0.335,0.598) | <0.0001 |
| NLR | 1474 | 867 | 3.064 | 0.6073 | 2.268 (1.709,3.010) | <0.0001 | 2.049 (1.530,2.743) | <0.0001 |
OR, odds ratio; 95% CI, 95%Confidence interval. Multivariate analysis adjusted for age, tumor location, tumor size and smoke. NEU, neutrophil; WBC, white blood cell; LYM, lymphocyte; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9; CA125, cancer antigen 125; ALB, albumin; ALP, alkaline phosphatase; GGT, gamma-glutamyl transpeptidase; Tp, total protein; NLR = neutrophil/lymphocyte.