Table 1.
Main characteristics of the included publications.
| First author | Year | Country | No. of patients | Site | Mean age (years) | TNM stage | Follow-up (months) | Claudin-1 expression | Detection method | Antibody | Cutoff value | High expression | Outcome | NOS (score) | Data extraction method |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Karabulut | 2015 | Turkey | 140 | Colorectal | 60.0 | I-IV | 14.0 | Serum | ELISA | YHB0737HU | >8.4 ng/ml | 50.0% | OS/DFS | 7 | K-M method |
| Matsuoka | 2011 | Japan | 156 | Colorectal | 65.0 | II-IV | 79.0 | Protein | IHC | E3411 | PP > 33% | 20.5% | OS/DFS | 8 | Univariate |
| Nakagawa | 2011 | Japan | 119 | Colorectal | NR | I-IV | 46.8 | mRNA | RT-PCR | NR | PP > median | 50.0% | OS/DFS | 8 | K-M method |
| Resnick | 2005 | USA | 129 | Colon | 72.5 | II | 96.0 | Protein | IHC | Polyclonal rabbit | SI ≥ 2 | 24.8% | OS/DFS | 9 | K-M method |
| Shibutani | 2013 | Japan | 344 | Colorectal | 66.8 | II-III | 51.7 | Protein | IHC | Polyclonal rabbit | PP > 25% | 68.0% | OS/DFS | 9 | K-M method |
| Singh | 2011 | USA | 250 | Colon | 64.6 | I-IV | 46.1 | Protein | IHC | Anti-claudin1 | >median | 50.0% | OS | 6 | K-M method |
| Yoshida | 2011 | Japan | 306 | Rectum | 64.0 | II-III | 38.0 | Protein | IHC | Monoclonal antibodies | PP > 30% | 46.7% | OS/DFS | 8 | K-M method |
| Kim | 2019 | Korea | 260 | Colon | 63.5 | I-IV | NR | Protein | IHC | Anti-claudin-1 | ISS ≥ 6 | 57.3% | OS/DFS | 8 | K-M method |
NR: not reported; IHC: immunohistochemistry; RT-PCR: reverse transcriptase polymerase chain reaction; SI: staining intensity; PP: positive cell percentage; immunostaining score (ISS) = PP∗SI; OS: overall survival; DFS: disease-free survival; K-M: Kaplan-Meier; NOS: Newcastle Ottawa Scale.