Table 2.
Meta-analysis of the correlation between claudin-1 expression and clinicopathological factors of colorectal cancer.
| Clinicopathological parameter | No. of studies | Participants | RR (95% CI) | Analysis model | Heterogeneity | Test for overall effect | ||
|---|---|---|---|---|---|---|---|---|
| I 2 (%) | P value | Z test | P value | |||||
| Tumor type (poorly vs. well) | 6 | 1312 | 0.60 (0.49, 0.73) | Fixed | 33 | 0.19 | 4.94 | <0.00001 |
| Venous invasion (+ vs. -) | 4 | 1029 | 0.81 (0.70, 0.95) | Fixed | 0 | 0.40 | 1.59 | 0.0010 |
| Lymphatic invasion (+ vs. -) | 4 | 1028 | 0.83 (0.74, 0.92) | Fixed | 0 | 0.42 | 3.32 | 0.0009 |
| Perineural invasion (+ vs. -) | 2 | 566 | 0.57 (0.25, 1.31) | Random | 80 | 0.03 | 1.33 | 0.18 |
| Depth of invasion (T3, 4 vs. T1, 2) | 4 | 1029 | 0.94 (0.72, 1.22) | Random | 70 | 0.02 | 0.47 | 0.64 |
| Lymph node metastasis (+ vs. -) | 4 | 1029 | 0.91 (0.82, 1.02) | Fixed | 0 | 0.60 | 1.66 | 0.10 |
| Distant metastasis (+ vs. -) | 2 | 379 | 0.88 (0.67, 1.15) | Fixed | 0 | 0.50 | 0.94 | 0.35 |
| TNM stage (III, IV vs. I, II) | 3 | 722 | 0.75 (0.54, 1.04) | Random | 69 | 0.04 | 1.71 | 0.09 |
| Size (larger vs. smaller) | 2 | 275 | 0.88 (0.60, 1.29) | Fixed | 0 | 0.68 | 0.65 | 0.52 |
| Gender (male vs. female) | 5 | 1185 | 1.02 (0.92, 1.14) | Fixed | 0 | 0.44 | 0.43 | 0.66 |
| Age (older vs. younger) | 2 | 275 | 1.15 (0.83, 1.60) | Fixed | 0 | 0.50 | 0.97 | 0.33 |
| Tumor site (colon vs. rectum) | 2 | 500 | 1.01 (0.87, 1.17) | Fixed | 0 | 0.81 | 0.10 | 0.92 |
RR: risk ratio; Random, random effects model; Fixed: fixed effect model.