TABLE 5.

The Risk Analysis of Transplant and Takedown Free Survival

	Univariable		Multivariable
Variables	HR (95% CI)	p Value	HR (95% CI)	p Value
HLHS	1.5 (1.1–2.1)	0.02	1.2 (0.7–2.3)	0.5
Heterotaxy	2.0 (1.2–3.3)	0.008	1.3 (0.6–2.5)	0.4
Morphologic RV	1.7 (1.2–2.4)	0.005	2.4 (1.3–4.6)	0.008
Age at Fontan (Y)	1.05 (1.03–1.08)	<0.0001	1.08 (1.03–1.1)	<0.001
PAP ≥ 15 mm Hg	1.7 (1.2–2.5)	0.004	1.6 (1.0–2.4)	0.03
CPB time (min)	1.01 (1.00–1.01)	0.007	1.0 (1.0–1.004)	0.6
Concomitant procedure	1.7 (1.2–2.4)	0.006	2.0 (1.3–3.0)	0.002
CT drain ≥2 wk	2.4 (1.7–3.5)	<0.0001	2.1 (1.3–3.4)	0.006
LOS (d)	1.02 (1.01–1.03)	<0.0001	1.01 (1.00–1.02)	0.001
Other than LT Fontan	2.3 (1.6–3.3)	<0.0001	2.0 (1.2–3.4)	0.006
AVVR ≥ moderate	1.8 (1.2–2.8)	0.006	2.4 (1.5–3.8)	<0.001

The risk analysis was performed using a Cox regression model with time-varying covariate for ventricular dysfunction and AVVR after Fontan. The reference groups of covariates are as follows: HLHS vs. non-HLHS, Heterotaxy vs. non-heterotaxy, morphologic RV vs. morphologic LV/2 ventricle morphology.

AVVR = atrioventricular valve regurgitation; BW = body weight; CI = confidence interval; CPB = cardiopulmonary bypass; CT = chest tube; HLHS = hypoplastic left heart syndrome; HR = hazard ratio; LOS = length of hospital stay; LT = lateral tunnel; PAP = pulmonary artery pressure; RV = right ventricle.