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. 2020 Aug 20;8(2):e000979. doi: 10.1136/jitc-2020-000979

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Transcriptional characterization of primary versus metastatic high-grade serous carcinomas (HGSCs). (A) Hierarchical clustering of 1468 transcripts (fold-change >2, adjusted p-value <0.05) that were significantly changed in paired 24 metastatic tumor microenvironment (M-TME) versus 24 primary tumor microenvironment (P-TME) samples from study group 1, as determined by RNA sequencing. (B) Gene Ontology (biological processes) enrichment analysis of differentially expressed in M-TME versus P-TME. See also online supplementary table 3. (C) Relative expression levels of gene sets associated with T cells, B cells, CD8⁺ T cells, dendritic cells (DCs), natural killer (NK) cells, T_H1 cells, T_H2 cells, monocytes, regulatory T (T_REG) cells, and myeloid-derived suppressor cells (MDSCs) across paired 24 P-TME and 24 M-TME samples, as determined by metagenes on RNA sequencing data from study group 1. Box plots: lower quartile, median, upper quartile; whiskers, minimum, maximum.