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. 2020 Aug 20;8(2):e000979. doi: 10.1136/jitc-2020-000979

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Prognostic impact of immune infiltrate in tumor microenvironment of primary and metastatic tissue of high-grade serous carcinoma (HGSC). (A) Representative images of lysosomal-associated membrane protein (DC-LAMP), CD20, CD8, and natural killer (NK) p46 immunostaining in primary tumor microenvironment (P-TME) and metastatic tumor microenvironment (M-TME) samples from study group 1. Scale bar=50 µm. (B) Density of DC-LAMP⁺, CD20⁺, CD8⁺ cells, and NKp46⁺ cells in paired 80 P-TME versus 80 M-TME samples from study group 1, as determined by immunostaining. Box plots: lower quartile, median, upper quartile; whiskers, minimum, maximum. (C and D) Overall survival (OS) of 80 patients from study group 1 on stratification based on median density of DC-LAMP⁺ cells, CD20⁺ cells, CD8⁺ cells, and NKp46⁺ cells in the P-TME (C) and M-TME (D). Survival curves were estimated by the Kaplan-Meier method, and differences between groups were evaluated using log-rank test. Number of patients at risk and p values are reported. ns, not significant.