Table 5.
Termination rates
| Author(s) | Study location | Study type | Study population | # of fetuses | # of fetuses terminated (%) |
| Africa | |||||
| de Paul Djientcheu et al22 | Cameroon | Retrospective descriptive observational study | Institutional; patients with NTDs | 8 | 0 (0%) |
| Shalaby et al95 | Egypt | Retrospective cross-sectional study | Institutional; patients with urinary anomalies | 41 | 11 (26.8%) |
| Sorri and Mesfin43 | Ethiopia | Retrospective cross-sectional study | Multi-centre; patients with NTDs at two tertiary hospitals | 177 | 13 (7.3%) |
| Akinmoladun et al44 | Nigeria | Prospective descriptive observational study | Institutional; patients with lethal congenital anomalies | 5 | 4 (80%) |
| Total | 4 studies, 4 countries | 3 retrospective, 1 prospective observational studies | 3 institutional, 1 multicentre | 231 | 28 Median: 17.1% Range: 0%–80% |
| Asia | |||||
| Li et al96 | China | Retrospective descriptive observational survey | Regional; patients with NTDs | 160 | 72 (45%) |
| Lu et al33 | China | Retrospective cross-sectional study | National (data from 20 counties); patients with NTDs | 361 | 355 (98.3%) |
| Xie et al91 | China | Retrospective descriptive observational study | Institutional; patients with bronchopulmonary sequestration | 22 | 8 (36.4%) |
| Zhang et al97 | China | Retrospective descriptive observational study | Institutional; patients with pulmonary sequestration | 68 | 2 (2.9%) |
| Kashyap et al98 | India | Retrospective descriptive observational study | Institutional; patients with lethal congenital anomalies detected prior to 20 weeks of gestation | 103 | 80 (77.7%) |
| Kumar et al99 | India | Prospective cohort study | Institutional; patients with severe renal anomalies | 55 | 9 (16.4%) |
| Kumar et al100 | India | Prospective descriptive observational study | Institutional; patients with renal anomalies | 136 | 12 (8.8%) |
| Sanghvi et al56 | India | Prospective descriptive observational study | Institutional; patients with lethal renal anomalies | 7 | 2 (28.6%) |
| Samadirad et al39 | Iran | Retrospective descriptive observational study | Regional; patients with congenital anomalies | 603 | 201 (33.3%) |
| Munim et al63 | Pakistan | Retrospective cohort study | Institutional; patients with diaphragmatic hernia | 41 | 6 (14.6%) |
| Hsieh et al101 | Taiwan | Retrospective descriptive observational study | Institutional; patients with CDH | 31 | 11 (35.5%) |
| Jaruratanasirikul et al102 | Thailand | Retrospective cross-sectional study | Regional; patients with NTDs | 28 | 12 (42.9%) |
| Pitukkijronnakorn et al64 | Thailand | Prospective cross-sectional study | Institutional; patients with congenital anomalies | 316 | 87 (27.5%) |
| Gammeltoft et al103 | Vietnam | Ethnographic study | Institutional; patients with congenital anomalies | 30 | 17 (56.7%) |
| Total | 14 studies, 7 countries | 9 retrospective, 4 prospective observational studies; 1 ethnographic study | 10 institutional, 3 regional, 1 national | 1961 | 874 Median: 34.4% Range: 2.9%–98.3% |
| Europe | |||||
| Tudorache et al71 | Romania | Retrospective descriptive observational study | Institutional; patients with severe CDH diagnosed in the second trimester of pregnancy | 6 | 4 (66.7%) |
| Aygun et al73 | Turkey | Retrospective descriptive observational study | Institutional; patients with NTDs | 72 | 0 (0%) |
| Oztarhan et al104 | Turkey | Retrospective cohort study | Institutional; patients with lethal congenital anomalies | 1906 | 640 (33.6%) |
| Sahinoglu et al77 | Turkey | Retrospective case series (6 cases) | Institutional; patients with body wall complex | 6 | 4 (66.7%) |
| Total | 4 studies, 2 countries | 4 retrospective observational studies | 4 institutional | 1990 | 648 Median: 50.2% Range: 0%–66.7% |
| North America | |||||
| Johnson et al42 | Jamaica | Retrospective descriptive observational study | Institutional; patients with congenital anomalies | 44 | 10 (22.7%) |
| Total | 1 study, 1 country | 1 retrospective observational study | 1 institutional | 44 | 10 Median: N/A Range: N/A |
| South America | |||||
| Brizot et al105 | Brazil | Retrospective descriptive observational study | Institutional; pairs of conjoined twins in which surgical separation was impossible and the condition lethal | 36 | 30 (83.3%) |
| Pelizzari et al106 | Brazil | Retrospective cohort study | Institutional; patients with anencephaly | 29 | 12 (41.4%) |
| Total | 2 studies, 1 country | 2 retrospective observational studies | 2 institutional | 65 | 42 (64.6%) Median: 62.4% Range: 41.4%–83.3% |
CDH, congenital diaphragmatic hernia; NTD, neural tube defects.