Table 2.

Best fit parameter estimates for the ODE model.

Untreated animals
Parameter		Animal 1	Animal 2	Animal 3	Animal 4	Animal 5
β ((copies/mL)-1(d)-1)		$2.89\times {10}^{-7}$	$3.12\times {10}^{-7}$	$2.12\times {10}^{-5}$	$1.00\times {10}^{-7}$	$9.91\times {10}^{-7}$
95% confidence interval		$(0.288-30.5)\times {10}^{-7}$	$(0.434-33.3)\times {10}^7$	$(0.0304-16.6)\times {10}^{-5}$	$(0.337-3.02)\times {10}^{-7}$	$(0.0430-88.1)\times {10}^{-7}$
p (copies/mL$\cdot$(d)-1)		$1.17\times {10}^9$	$1.46\times {10}^9$	$2.72\times {10}^7$	$5.61\times {10}^9$	$1.08\times {10}^9$
95% confidence interval		$(0.105-13.4)\times {10}^9$	$(0.161-12.4)\times {10}^9$	$(1.68-38.3)\times {10}^7$	$(1.91-17.3)\times {10}^9$	$(0.497-49.8)\times {10}^9$
δ (/d)		2.77	3.18	1.63	2.26	1.55
95% confidence interval		1.92–3.81	2.49–3.89	1.39–1.98	1.92–2.61	1.16–2.16
$R_0$		12.2	14.3	35.3	24.9	69.1
95% confidence interval		6.77–19.8	9.92–21.4	3.19–466	20.7–31.0	2.52–631
$t_{\text{inf}}$ (h)		1.85	1.59	1.42	1.43	1.04
95% confidence interval		1.54–2.27	1.34–1.90	0.389–4.51	1.32–1.54	0.353–5.08
SSR		6.56	4.76	2.19	1.22	6.59
95% confidence interval	1.10–7.85	0.159–6.76	0.530–3.19	0.107–1.66	0.766–10.4
Treated animals
	Animal 6	Animal 7	Animal 8	Animal 9	Animal 10
β ((copies/mL)-1(d)-1)	$1.17\times {10}^{-5}$	$6.67\times {10}^{-6}$	$5.04\times {10}^{-6}$	$5.94\times {10}^{-7}$	$3.88\times {10}^{-7}$
95% confidence interval	$(0.139-105)\times {10}^{-5}$	$(1.76-520)\times {10}^{-6}$	$(0.0332-41.3)\times {10}^{-6}$	$(1.64-63.3)\times {10}^{-7}$	$(1.63-211)\times {10}^{-7}$
p (copies/mL$\cdot$(d)-1)	$2.65\times {10}^7$	$6.71\times {10}^7$	$1.25\times {10}^8$	$8.64\times {10}^8$	$1.72\times {10}^9$
95% confidence interval	$(0.468-33.0)\times {10}^7$	$(2.66-25.1)\times {10}^7$	$(0.732-38.6)\times {10}^8$	$(2.47-31.7)\times {10}^8$	$(0.967-4.84)\times {10}^9$
δ (/d)	0.457	0.789	0.729	1.66	1.40
95% confidence interval	0.0679–1.10	0.480–1.16	0.358–1.36	1.25–2.07	1.21–1.66
$R_0$	67.7	56.8	86.3	30.94	47.8
95% confidence interval	27.3–1230	36.6–533	2.69–116	23.4–570	36.8–494
$t_{\text{inf}}$ (h)	1.93	1.60	1.35	1.50	1.31
95% confidence interval	0.00316–2.25	0.0180–1.75	0.400–6.16	0.397–1.67	0.0132–1.43
SSR	3.78	1.15	6.51	1.72	0.520
95% confidence interval	0.741–4.56	0.193–1.35	0.981–10.6	0.194–2.30	0.0910–0.673