Table 1.

Clinical feature and experimental results of cytokines tested in mouse serum.

Cytokines	Elevated in COVID-19 [2,29]	Higher in Severe Cases [2,29]	Control (pg/mL)	Entecavir (pg/mL)	P	Trend	Imipenem (pg/mL)	P	Trend
TNF-α	Yes	Yes	1737.23 ± 69.58	1243.4 ± 80.85	<0.001	↓	1112.77 ± 35.33	<0.001	↓
IL-6	Yes	No	99796.23 ± 2181.37	82363.29 ± 5849.85	0.002	↓	77589.85 ± 3969.16	<0.001	↓
IFN-α	No Data	No Data	648.73 ± 10.58	459.80 ± 29.63	<0.001	↓	379.79 ± 18.95	<0.001	↓
IFN-γ	Yes	No	1572.54 ± 96.17	871.49 ± 63.01	<0.001	↓	861.25 ± 69.08	<0.01	↓
IL-1β	Yes	No	544.17 ± 32.01	355.03 ± 39.37	<0.001	↓	270.55 ± 29.68	<0.001	↓
IL-10	Yes	Yes	1028.75 ± 46.15	889.50 ± 94.24	0.24	−	878.69 ± 52.15	0.052	−
IL-12	No	No	243.11 ± 5.65	128.27 ± 10.27	<0.001	↓	98.62 ± 6.91	<0.001	↓
CXCL1	No Data	No Data	30068.23 ± 3912.14	26227.69 ± 1877.58	0.91	−	34548.18 ± 12416.35	0.58	−
IP10	Yes	Yes	41395.54 ± 1787.44	35897.97 ± 1743.83	0.007	↓	37422.71 ± 1594.13	0.09	−
MCP-1	Yes	Yes	36035.98 ± 578.19	28332.26 ± 1719.45	0.002	↓	32098.47 ± 897.84	0.023	↓
CCL-5	No Data	No Data	12449.74 ± 840.43	11270.31 ± 570.41	0.80	−	10020.8 ± 748.60	0.25	−
GM-CSF	Yes	No	223.71 ± 8.98	190.58 ± 11.68	0.039	↓	158.05 ± 7.09	<0.001	↓