Table 2.
Clinical feature and experimental results of cytokines tested in mouse BALF.
| Cytokines | Elevated in COVID-19 | Higher in Severe Cases | Control (pg/mL) | Entecavir (pg/mL) | P | Trend | Imipenem (pg/mL) | P | Trend |
|---|---|---|---|---|---|---|---|---|---|
| TNF-α | No Data | No Data | 26.39 ± 4.53 | 6.24 ± 1.40 | <0.001 | ↓ | 5.86 ± 1.13 | <0.001 | ↓ |
| IL-6 | No Data | No Data | 10176.96 ± 2354.05 | 2542.99 ± 796.29 | 0.006 | ↓ | 1407.38 ± 221.92 | 0.002 | ↓ |
| IFN-β | No Data | No Data | 30.92 ± 5.65 | 17.17 ± 5.28 | <0.001 | − | 13.49 ± 2.86 | 0.02 | ↓ |
| IFN-γ | No Data | No Data | 67.02 ± 20.29 | 27.09 ± 8.45 | <0.001 | − | 32.24 ± 8.20 | 0.39 | − |
| IL-1α | No Data | No Data | 180.92 ± 50.29 | 30.42 ± 9.84 | 0.018 | ↓ | 25.65 ± 2.98 | 0.014 | ↓ |
| IL-1β | No Data | No Data | 28.99 ± 5.99 | 17.67 ± 2.08 | 0.24 | − | 15.98 ± 1.58 | 0.045 | ↓ |
| IL-10 | No Data | No Data | 43.11 ± 12.99 | 9.10 ± 3.56 | <0.001 | ↓ | 2.64 ± 1.60 | 0.008 | ↓ |
| IL-17A | No Data | No Data | 26.81 ± 11.91 | 7.08 ± 2.52 | 0.91 | − | 5.45 ± 1.56 | 0.098 | − |
| IL-23 | No Data | No Data | 9.49 ± 1.87 | 7.73 ± 1.28 | 0.477 | − | 4.82 ± 1.33 | 0.061 | − |
| IL-27 | No Data | No Data | 22.16 ± 3.39 | 6.18 ± 1.52 | <0.001 | ↓ | 2.66 ± 0.58 | <0.001 | ↓ |
| MCP-1 | No Data | No Data | 900.08 ± 285.4 | 207.84 ± 75.47 | 0.80 | − | 195.56 ± 43.45 | 0.035 | ↓ |
| GM-CSF | No Data | No Data | 7.50 ± 1.38 | 3.09 ± 1.09 | 0.031 | ↓ | 3.42 ± 0.75 | 0.02 | ↓ |