Fig. 2.

(A) Taken with permission from Mohiuddin et al,²⁵ a patient with an uncontrolled 18-cm nodal melanoma mass, progressing after IL-2, ipilumimab, and pembrolizumab. The authors treated with 20-Gy SFRT followed by 50-Gy conventional EBRT and pembrolizumab with a complete and sustained response. (B) Taken with permission from Kaiser et al,²⁶ a rapidly progressing upper extremity spindle cell sarcoma despite conventional EBRT was treated with 18-Gy GRID boosted by 32-Gy EBRT. Tumor regression was 90%, including gross tumor involving the medial humerus that was shielded. Abbreviations: EBRT = external beam radiation therapy; SFRT = spatially fractionated radiation therapy.