Table 2.
Summary of clinical studies
| Authors | Treated Sites (n) | Follow-up, median (range) (mo) | Histology | GRID dose, median (range) (Gy) | Prior RT | GRID only | Control rates | Side effects |
|---|---|---|---|---|---|---|---|---|
| Mohiuddin et al, 19905 | 22 | NR (1-18) | Diverse | NR (10-15) | 27% | 36% | Response rate: 91% | 1 acute skin erythema, 2 N&V, 2 diarrhea, 1 late SBO |
| Mohiuddin et al, 19967 | 72 | 4 (0.5-28) | Diverse | NR (10-25) | 24% | 44% | Response rate: 91% | No grade 2 or higher acute toxicity |
| Mohiuddin et al, 199918 | 87 | 7 (3-42) | Diverse | 15 (10-20) | 9% | 20% | Response rate: 91% | 1 grade 3 acute mucositis, 1 fatal carotid blowout |
| Kudrimoti et al, 200219 | 20 | NR | Melanoma | 15 (12-20) | 25% | 25% | Response rate: 80% | No grade 3 or higher toxicities |
| Huhn et al, 200622 | 27 | 10 (3-44) | SCC of H&N | 15 (15-20) | 0% | 0% | (1) Neck control rate: 93%; (2) neck control rate 92% | (1) acute G 2-3 skin toxicity, 10 late G 2 soft tissue and muscle fibrosis; (2) 3 poor postoperative wound healing, 4 fibrosis limiting neck movement |
| Mohiuddin et al, 200920 | 44 | 9 (2-44) | Soft tissue sarcoma | 15 (12-20) | NR | 9% | Response rate 76% | 2 G 3 acute skin reactions |
| Penagaricano et al, 201023 | 14 | 19.5 (2-38) | SCC of H&N | 20 | 0% | 0% | Local control rate: 79% | 1 fatal carotid blowout, 11 acute G 2-3 skin reaction, 13 acute G 2-3 mucosal reaction, 4 late G 2-3 skin fibrosis |
| Neuner et al, 201213 | 79 | 2 (0-51.6) | Diverse | 15 (10-20) | NR | 20% | Pain response rate, block: 95%, pain response rate, MLC: 74%, mass effect response rate, block: 84%, mass effect response rate, MLC: 79% | 4 G 3-4 acute skin reactions with block versus 10 G 3-4 acute skin reactions with MLC |
| Mohiuddin et al, 201421 | 14 | 14 (3-43) | Soft tissue sarcoma | 18 | 0% | 0% | Local control rate: 100% | 1 G 3 acute skin, 2 delayed wound healing |
| Edwards et al, 201524 | 53 | mean 34 (1-239) | SCC of H&N | 15 | NR | 0% | Local control rate: 81% | 2 late toxicities requiring feeding tubes |
Abbreviations: G = grade; H&N = head and neck; MLC = multileaf collimator; N&V = nausea and vomiting; NR = not reported; RT = radiation therapy; SCC = squamous cell carcinoma.