Table 5. Logistic regression analyses for SNPs as predictors of infiltration patterns of CD8+, PD1+, FOXP3+ and CD57+ lymphocytes.
| Gene and polymorphism | CD8- follicular | PD1- follicular | FOXP3- follicular | CD57- follicular | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| IL12A rs568408 | ||||||||
| GG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| GA+AA | 3.03 (0.67–13.55) | 0.14 | 0.73 (0.24–2.24) | 0.59 | 3.07 (1.10–8.56) | 0.03 | 2.66 (0.68–10.39) | 0.15 |
| AA | 5.05 (0.39–64.73) | 0.21 | 58 (0–∞) | 0.99 | 7.52 (0.69–81.54) | 0.09 | 1.51 (0.14–15.75) | 0.72 |
| GG+GA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| AA | 3.40 (0.30–38.73) | 0.32 | 58 (0–∞) | 0.99 | 5.88 (0.56–61.65) | 0.13 | 3.48 (0.34–35.23) | 0.29 |
| IL12A rs755004 | ||||||||
| GG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| GA+AA | 1.61 (0.17–14.66) | 0.67 | 1.18 (0.36–3.90) | 0.77 | 1.03 (0.33–3.18) | 0.95 | 0.78 (0.21–2.85) | 0.71 |
| IL12A rs485497 | ||||||||
| AA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| AG+GG | 0.75 (0.13–4.12) | 0.74 | 1.34 (0.45–3.98) | 0.59 | 0.43 (0.15–1.22) | 0.11 | 0.19 (0.06–0.58) | 0.003 |
| GG | 0.74 (0.09–6.03) | 0.78 | 1.47 (0.75–2.88) | 0.25 | 0.56 (0.15–2.12) | 0.39 | 0.30 (0.07–1.24) | 0.09 |
| AA+AG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| GG | 0.94 (0.17–5.14) | 0.94 | 2.53 (0.85–7.48) | 0.09 | 1.00 (0.34–2.90) | 0.99 | 0.70 (0.19–2.47) | 0.58 |
| IL12A rs583911 | ||||||||
| AA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| AG+GG | 2.56 (0.28–22.70) | 0.39 | 3.46 (1.20–9.97) | 0.02 | 2.07 (0.71–6.01) | 0.17 | 1.88 (0.60–5.88) | 0.27 |
| GG | 0.41 (0.03–5.18) | 0.49 | 0.29 (0.06–1.27) | 0.10 | 0.74 (0.17–3.11) | 0.68 | 1.17 (0.30–4.53) | 0.81 |
| AA+AG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| GG | 1.43 (0.24–8.31) | 0.68 | 2.01 (0.51–7.80) | 0.31 | 0.88 (0.29–2.61) | 0.82 | 0.40 (0.13–1.27) | 0.12 |
| IL2 rs2069762 | ||||||||
| TT | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| TG+GG | 1.45 (0.30–7.06) | 0.63 | 0.58 (0.21–1.60) | 0.30 | 1.35 (0.54–3.32) | 0.51 | 0.65 (0.24–1.80) | 0.41 |
| IL2 rs6822844 | ||||||||
| GG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| GT+TT | N/E | N/E | 2.67 (0.55–12.81) | 0.21 | 0.78 (0.25–2.37) | 0.66 | 0.56 (0.18–1.75) | 0.32 |
| IL10 rs1800872 | ||||||||
| CC | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| CA+AA | 8.87 (1.03–76.10) | 0.04 | 3.59 (1.17–11.0) | 0.02 | 2.45 (0.99–6.06) | 0.05 | 2.43 (0.87–6.77) | 0.08 |
| AA | N/E | N/E | 6.75 (1.27–35.89) | 0.02 | 1.58 (0.32–7.63) | 0.56 | 8.30 (1.06–64.80) | 0.04 |
| CC+CA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| AA | N/E | N/E | 3.44 (0.80–14.69) | 0.09 | 1.02 (0.22–4.58) | 0.97 | 5.35 (0.84–33.94) | 0.07 |
| IL10 rs3024491 | ||||||||
| CC | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| CA+AA | 5.17 (0.57–47.00) | 0.14 | 2.93 (0.78–10.88) | 0.10 | 1.03 (0.35–2.97) | 0.95 | 1.22 (0.39–3.76) | 0.72 |
| AA | N/E | N/E | N/E | N/E | 0.63 (0.05–7.06) | 0.71 | 1.84 (0.15–21.83) | 0.62 |
| CC+CA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| AA | N/E | N/E | N/E | N/E | 0.56 (0.05–5.93) | 0.63 | 1.40 (0.13–14.79) | 0.77 |
| IL10 rs1800890 | ||||||||
| TT | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| TA+AA | 4.25 (0.72–24.91) | 0.10 | 2.13 (0.52–8.71) | 0.29 | 2.44 (0.83–7.16) | 0.10 | 1.52 (0.47–4.88) | 0.48 |
| AA | N/E | N/E | N/E | N/E | 1.29 (0.10–16.01) | 0.84 | N/E | N/E |
| TT+TA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| AA | N/E | N/E | N/E | N/E | 0.87 (0.07–10.46) | 0.91 | N/E | N/E |
| TGFB1 rs1800469 | ||||||||
| CC | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| CT+TT | 2.17 (0.37–12.61) | 0.38 | 1.39 (0.41–4.69) | 0.59 | 0.81 (0.27–2.36) | 0.70 | 0.72 (0.23–2.23) | 0.57 |
| TT | 22.8 (1.15–450.48) | 0.04 | 0.93 (0.07–11.22) | 0.95 | 1.78 (0.20–15.43) | 0.60 | 0.57 (0.02–11.90) | 0.72 |
| CC+CT | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| TT | 24.38 (1.62–366.71) | 0.02 | 0.64 (0.06–6.77) | 0.71 | 1.95 (0.25–15.27) | 0.52 | 0.51 (0.02–9.19) | 0.65 |
| TGFB1 rs1800471 | ||||||||
| GG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| GC+CC | 1.92 (0.19–19.28) | 0.57 | N/E | N/E | 2.22 (0.49–10.03) | 0.29 | 1.21 (0.21–6.90) | 0.82 |
| TGFB1 rs6957 | ||||||||
| AA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| AG+GG | 2.18 (0.45–10.47) | 0.33 | 1.04 (0.38–2.87) | 0.93 | 1.50 (0.61–3.66) | 0.37 | 1.09 (0.39–3.00) | 0.86 |
| GG | N/E | N/E | 0.10 (0.00–1.35) | 0.08 | N/E | N/E | N/E | N/E |
| AA+AG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| GG | N/E | N/E | 0.07 (0.00–1.00) | 0.05 | N/E | N/E | N/E | N/E |
| TGFBR1 rs334348 | ||||||||
| AA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| AG+GG | 1.73 (0.31–9.72) | 0.52 | 2.67 (0.96–7.43) | 0.05 | 0.83 (0.33–2.09) | 0.69 | 0.87 (0.31–2.43) | 0.79 |
| GG | N/E | N/E | N/E | N/E | N/E | N/E | 0.54 (0.02–12.90) | 0.70 |
| AA+AG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| GG | N/E | N/E | N/E | N/E | N/E | N/E | 0.67 (0.03–12.28) | 0.79 |
| TGFBR2 rs3087465 | ||||||||
| GG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| GA+AA | 0.52 (0.11–2.40) | 0.40 | 0.73 (0.27–1.95) | 0.54 | 1.39 (0.57–3.37) | 0.46 | 0.94 (0.35–2.56) | 0.91 |
| AA | N/E | N/E | 0.07 (0.0–0.84) | 0.03 | 2.58 (0.30–22.13) | 0.38 | N/E | N/E |
| GG+GA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| AA | N/E | N/E | 0.07 (0.0–0.76) | 0.03 | 2.17 (0.27–17.19) | 0.46 | N/E | N/E |
| IL17A rs3748067 | ||||||||
| CC | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| CT+TT | 0.31 (0.03–2.81) | 0.30 | 0.50 (0.18–1.41) | 0.19 | 0.70 (0.25–1.93) | 0.49 | 0.59 (0.20–1.70) | 0.33 |
| IL17F rs763780 | ||||||||
| TT | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
| TC+CC | 0.63 (0.10–3.64) | 0.60 | 0.40 (0.14–1.15) | 0.09 | 0.70 (0.26–1.87) | 0.48 | 0.63 (0.20–1.92) | 0.41 |
OR (95%CI) = Odds ratio with 95% confidence interval. N/E = Not evaluable (OR = zero or OR = ∞).