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Control of Nodal signaling by various regulators in the developing vertebrate embryo. The Nodal signaling pathway in vertebrate embryos (Nodal → receptor → Smad2/3/4 → FoxH1 → target genes) is regulated in a spatiotemporal manner at multiple levels by various inhibitors including Lefty, Cerberus (Cerl2), Ectodermin (Ecto), Drap1, and miR-430 (left panel). Nodal and Lefty also participate in positive and negative regulatory loops (right panel).
