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. 2020 Aug 19;13:8233–8243. doi: 10.2147/OTT.S243040

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© 2020 Wang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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CircEXOC6B functions as a ceRNA of miR-421 in ovarian cancer. (A) The 3ʹ‐UTR of circEXOC6B harbors miR-421 cognate sites. (B) The level of miR-421 in SKOV3 cells transfected with miR-421 agonist or miR-421 antagonist was detected by qRT-PCR. (C) Relative luciferase activity of reporter plasmids carrying WT or MT circEXOC6B 3ʹ‐UTR in SKOV3 cells following co‐transfecting with miR-421 were measured using dual-luciferase reporter assay. (D) Co-localization between circEXOC6B (red) and miR-421 (green) was observed (arrowheads) by FISH in SKOV3 cells. **P < 0.01, compared with the NC group.

Abbreviation: NC, negative control.