Table 1.
Relationship of 15-PGDH Expression with Clinicopathologic Parameters and FOXP3 in GC
| n | 15-PGDH Expression | P-value | ||||
|---|---|---|---|---|---|---|
| 0 (n=6) | 1 (n=28) | 2 (n=15) | 3 (n=43) | |||
| Sex | ||||||
| Male | 71 | 4 | 23 | 12 | 32 | 0.796 |
| Female | 21 | 2 | 5 | 3 | 11 | |
| Age | ||||||
| <55 | 44 | 4 | 15 | 5 | 20 | 0.472 |
| ≥55 | 48 | 2 | 13 | 10 | 23 | |
| Differentiation | ||||||
| Tubular | 27 | 1 | 13 | 1 | 12 | 0.043 |
| Poor | 65 | 5 | 15 | 14 | 31 | |
| Invasion depth | ||||||
| T1/T2 | 21 | 0 | 5 | 3 | 13 | 0.311 |
| T3/T4 | 71 | 6 | 23 | 12 | 30 | |
| Lymph node metastasis | ||||||
| No | 55 | 2 | 12 | 11 | 30 | 0.046 |
| Yes | 37 | 4 | 16 | 4 | 13 | |
| TNM stage | ||||||
| I+II | 32 | 2 | 5 | 5 | 20 | 0.104 |
| III+IV | 60 | 4 | 23 | 10 | 23 | |
| FOXP3 expression | ||||||
| Low | 55 | 1 | 13 | 6 | 35 | 0.001 |
| High | 37 | 5 | 15 | 9 | 8 | |
Abbreviations: T2, tumour invasion of the muscularis propria or subserosa; T3, tumour invasion extends to or beyond the serosa; T4, tumour invasion of adjacent structures; Tubular, tubular adenocarcinoma; Poor, poorly differentiated adenocarcinoma.