Figure 1.

Clinical and laboratory data in patient with post–cardiac surgery SRA‐negative HIT who required urgent repeat cardiac surgery. The top panel shows the serial platelet counts, anticoagulant administration, and other key events. The middle section shows serial CLIA, GTI‐GAM (commercial polyspecific anti‐PF4/polyvinyl sulfonate EIA [LIFECODES PF4 Enhanced, Immucor GTI Diagnostics,Inc]), GTI‐G (commercial IgG specific anti‐PF4/polyvinyl sulfonate EIA [LIFECODES PF4 IgG,Immucor GTI Diagnostics,Inc]), and EIA‐G (in‐house IgG‐specific EIA of the McMaster Platelet Immunology Laboratory). The lower panel shows the percent serotonin‐release (100 ug mL^‐1 PF4). CLIA, chemiluminenscence immunoassay; CPB, cardiopulmonary bypass; Echo, echocardiogram; EIA‐G, IgG‐specific enzyme‐immunoassay; GTI‐G, IgG‐specific enzyme‐immunoassay from GTI Diagnostics; GTI‐GAM, polyspecific enzyme‐immunoassay from GTI Diagnostics; HIT, heparin‐induced thrombocytopenia; IVIG, intravenous immunoglobulin; NSQ, not sufficient quantity; PF4, platelet factor 4