. 2020 Aug 23;37(9):171. doi: 10.1007/s11095-020-02908-7

Table II.

The Vancomycin PopPK Model (10)

Component	Equation
Pharmacokinetic parameters	CL (L/h) = 4.58·CrCL/100·e^η₁ V (L) = 1.53 ·WGT·e^η₂
Inter-individual variability	η₁ ~ N(0, $ω_{1}^{2}$ ) and η₂ ~ N(0, $ω_{2}^{2}$ ) ω₁= 0.389 and ω₂ = 0.374
Residual errors	Obs = Pred·(1 + ε₁) + ε₂ ε₁~ N(0, $σ_{1}^{2}$ ) and ε₂ ~ N(0, $σ_{2}^{2}$ ) σ₁ = 0.199 and σ₂ = 2.4 (mg/L)

Component

Equation

Pharmacokinetic parameters

CL (L/h) = 4.58·CrCL/100·e^η₁

V (L) = 1.53 ·WGT·e^η₂

Inter-individual variability

η₁ ~ N(0, $ω_{1}^{2}$ ) and η₂ ~ N(0, $ω_{2}^{2}$ )

ω₁= 0.389 and ω₂ = 0.374

Residual errors

Obs = Pred·(1 + ε₁) + ε₂

ε₁~ N(0, $σ_{1}^{2}$ ) and ε₂ ~ N(0, $σ_{2}^{2}$ )

σ₁ = 0.199 and σ₂ = 2.4 (mg/L)

CL, clearance; V, volume of distribution; CrCL, creatinine clearance in ml/min; WGT, body weight in kg; Obs, observed concentration; Pred, predicted concentration