Table 3.
Univariate and Multivariate Survival Analyses of OS in Patients with ESCC
| Univariate Analysis | *Multivariate Analysis | |||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (≥60 vs <60) | 1.203 (0.758–1.908) | 0.4332 | ||
| Gender (Male vs Female) | 2.012 (0.873–4.641) | 0.100 | ||
| BMI (≥24 vs <24) | 1.188 (0.750–1.882) | 0.4624 | ||
| Smoking history (Yes vs No) | 1.618 (0.923–2.836) | 0.0931 | ||
| Tumor location (Lower vs Upper + Middle) | 1.231 (0.694–2.182) | 0.4777 | ||
| Pathologic M (M1 vs M0) | 3.695 (2.134–6.397) | <0.0001 | 2.296 (1.247–4.225) | 0.0076 |
| Pathologic N (N2–N3 vs N0–N1) | 2.066 (1.182–3.610) | 0.0109 | ||
| Pathologic T (T3–T4 vs T1–T2) | 1.591 (0.992–2.551) | 0.054 | ||
| Grade (G3–G4 vs G1–G2) | 2.107 (1.293–3.433) | 0.0028 | ||
| Recurrence (Yes vs No) a | 2.546 (1.549–4.184) | <0.0001 | 2.184 (1.298–3.672) | 0.0032 |
| Tissue Δ133p53/p53 ratio (≥ 2.6470 vs < 2.6470) | 4.496 (2.742–7.375) | <0.0001 | 3.864 (2.293–6.511) | <0.0001 |
| Serum Δ133p53/p53 ratio (≥ 2.9160 vs < 2.9160) | 2.559 (1.617–4.050) | <0.0001 | 2.503 (1.465–4.276) | 0.0011 |
Notes: a149 of 180 patients with regular follow–up checks for recurrence after surgery. Univariate and multivariate Cox survival (Forward Stepwise Likelihood Ratio method) analyses were applied to assess the hazard ratios (HRs) and P value. *Adjusting for age, gender, BMI, smoking history, tumor location, pathologic M, N and T stage, grade, recurrence, tissue Δ133p53/p53 ratio and serum Δ133p53/p53 ratio, respectively.