Table 3.

Univariate and Multivariate Analyses of Factors Potentially Predicting for OS and LRRFS

Factors	N	OS (%)				LRRFS (%)
		Univariate Analysis		Multivariate Analysis		Univariate Analysis		Multivariate Analysis
		Five Years	P	P	RR	Five Years	P	P	RR
Gender
Male	41	55.3	0.106			66.5	0.027	0.194	0.031
Female	12	83.3				100			(0.000–5.889)
Age
≤60	24	49.7	0.048	0.170	0.525	64.5	0.140	0.264	0.523
>60	29	70.7			(0.209–1.317)	82.2			(0.168–1.630)
Nodal staging
N0	23	64.3	0.614	0.455	0.646	73.4	0.864	0.482	0.657
N1	30	58.8			(0.205–2.032)	75.3			(0.203–2.122)
Tumor location
Cervical+upper thoracic location	24	63.9	0.573			82.5	0.277
Middle thoracic	29	58.2				67.4
TNM staging
II staging	18	71.3	0.523	0.345	1.393	77.0	0.704	0.329	1.680 (0.593–4.759)
III	25	55.9			(0.700–2.775)	75.7
IV	9	55.6				66.7
Pretreatment GTVe GTVe
≤22cc	26	76.3	0.033	0.006	4.033	83.9	0.118	0.040	3.668
>22cc	27	46.4			(1.485–10.957)	64.7			(1.058–12.717)
GTVe at 20th Fraction of RT fraction
≤13cc	26	72.4	0.110	0.158	0.250 (0.037–1.717)	83.3	0.127	0.734	1.711 (0.077–37.994)
>13cc	27	50.3				65.4
GTVe at completion of treatment
≤13 cc	27	73.5	0.069	0.460	0.661 (0.220–1.983)	80.7	0.287	0.448	0.506 (0.087–2.945)
>13 cc treatment	26	48.2				67.3
GTVe three months after treatment
≤12 cc	26	79.6	0.005	0.182	0.502 (0.182–1.381)	84.4	0.089	0.64	1.012
>12cc	27	43.3				64.2			(0.962–1.065)
GTVe RR at twentieth fraction of RT
<35%	25	47.7	0.041	0.007	0.267	64.8	0.207	0.059	0.319 (0.098–1.044)
≥35%	28	73.0			(0.103–0.694)	81.8
GTVe RR at completion of treatment
<38%	26	53.8	0.274	0.466	1.015 (0.975–1.057)	66.2	0.366	0.424	0.560 (0.135–2.319)
≥38%	27	67.9				81.3
GTVe RR three months after treatment
<35%	24	50.0	0.079	0.182	0.502	66.4	0.407	0.445	0.627
≥35%	29	70.0			(0.182–1.381)	79.3			(0.189–2.081)

Abbreviations: GTVe, gross tumor volume of esophagus; RT, radiotherapy; RR, reduction ratio.