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Antinociceptive activity of cyclo[Pro‐Sar‐Phe‐d‐Phe] following administration i.c.v. (a) or i.p. (b) in the 55°C warm‐water tail‐withdrawal assay in C57BL/6J mice. cyclo[Pro‐Sar‐Phe‐d‐Phe] demonstrated significant time‐ and dose‐dependent antinociception with repeated measurement over time. Data shown are the % antinociception (as means ± SEM) from six to 24 mice for each set presented; overall, results from 129 mice are presented
