FIGURE 7.

Effect of AKAP5 depletion on the potentiation of DHPG‐induced pain behaviour in mice with inflammation. (a) Expression of AKAP5 protein in the DRGs of AKAP5 KO mice. (b) Timeline of experimental procedures (top). Tests were conducted 3 days after intraplantar (i.pl.) injection of CFA (open arrow). Effects of CFA on footpad thickness (bottom left) and on DHPG‐induced pain behaviour (bottom right) in AKAP5 KO mice (n = 8). (c) Changes in the percentages of DHPG‐sensitive neurons after NGF treatment using DRGs dissociated from AKAP5 KO mice (n = 8). Each column and vertical bar represent mean ± SEM (n =8); open circles indicate the individual values. *P < 0.05, significantly different from the control group; unpaired t‐test