. Author manuscript; available in PMC: 2021 Sep 15.

Published in final edited form as: Bioorg Med Chem. 2020 Jul 17;28(18):115644. doi: 10.1016/j.bmc.2020.115644

Table 1.

Comparison of Inhibitor Potency^a

	Percent Inhibition from Primary	IC₅₀ (μM)^a	K_i (μM)^a	Inhibition Mechanism^a

Nitroflurazone	27	90 ± 10	120 ± 20	Noncompetitive
Phenazopyridine Hydrochloride	44	145 ± 2	70 ± 10	Competitive
Doxycycline Hydrochloride	26	145 ± 2	280 ± 40	Noncompetitive
Berberine Chloride	70	140 ± 20	130 ± 10	Noncompetitive
Pyrithone Zinc	72	20 ± 2	15 ± 2	Noncompetitive
Zinc Chloride	NA	10 ± 1	3.3 ± 0.1	Noncompetitive

Values determined using bacterially expressed SARM1 TIR domain lysates.