FIGURE 1.

BRG1 regulates NO bioavailability by modulating eNOS phosphorylation in mice. 8-week male Apoe^–/– mice were injected with lentivirus carrying endothelial-specific BRG1 shRNA (Endo-shBRG1) or the control virus (shC) and fed a Western diet or a control diet for 8 weeks as described in “Materials and Methods.” (A) Aortic arteries were homogenized and NO content was examined using the Griess assay. (B,C) Gene expression levels in the aortic arteries were examined by qPCR and Western. N = 5 mice for the control diet groups and N = 7 mice for the Western diet groups. *p < 0.05.