FIGURE 4.

Pretreatment with dexamethasone/tariquidar does not significantly affect CED infusate distribution. Representative serial MRI at multiple time points of A, an animal that had CED of dasatinib/gadoteridol and B, an animal pretreated with dexamethasone and tariquidar prior to CED of dasatinib/gadoteridol. C, There were no differences in the MRI signal intensity curves of animals pretreated with dexamethasone and tariquidar (dex/tar, gray lines) and those not pretreated (black lines). D, A random coefficient model with an unstructured covariance structure showed no difference in the mean slope of signal intensity within each treatment group, indicating comparable infusate dispersion rates. White circle = region of interest of MRI signal intensity.