Fig. 1.

Schematic diagram of chromosome 4 showing the location and arrangement of GYPA, GYPB,and GYPE genes. Based on the GRCh38/hg38 assembly, the arrangement and location of the MNS blood group gene cluster is located on Chr4 q31.21 [2, 3]. The GenBank NG_007470 reference sequence was used as the basis for GYPA exon 3 sequence [37]. The nucleotide position c.140 is shown on GYPA exon 3. The molecular basis for GYP*Hut is c.140C>A (p.Thr47Lys) and that for GYP*Vw is c.140C>T (p.Thr47Met). Arrows above show the direction of transcription.