Table 1.

Comparison of conventional squamous cell carcinoma therapies and risks of severe cutaneous side effects

Therapy for squamous cell carcinoma	Side effects
Chemotherapies: alkylating agents, anthracyclines, antimetabolites, antineoplastics [6]	- neutropenia - severe skin infections - severe septicemia
Epidermal growth factor receptor - tyrosine kinase inhibitors: cetuximab, erlotinib, panitumumab [7]	- acneiform eruptions - skin irritation - increased risk of infection and septicemia
Risk factors in patients with recessive dystrophic epidermolysis bullosa  Increased skin fragility  Large chronic wounds  Frequent wound infections, often with multi-drug-resistant bacteria  Chronic inflammatory state